Not literally a pain in one's anus or gluteus maximus, though either would count.
Something quite annoying, but not as bad as a ballache, which would also be expected to last longer.
People, Places, Things: it doesn't matter. Often shortened to just: a pain.
Was that your uncle?
Yeah. What a pain in the arse.
Well, i wasn't gonna say anythin, but...
You wanna meet my Dad! What a ballache. Shit, he's coming over, time for a cool sharp one.
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A term to use when you find something hard to do.
"That coursework was a pain in the arse for me"
Samuel Launiere
Samuel Launiere in the biggest pain in the arse