to be permanently effected by drugs, even after not taking them for a while.
i don't think weed or acid permafry people, but cocaine will change someone for life.
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v 1. to appear as if on drugs, even though one is sober.
"Wow that Mark Fry kid is perma-fried."
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which the user of the drug (mainly LSD) feels some effects of the drug (example; sever memory loss) for a vary long time after use of the drug year possibly longer ( the conduction will get better over time but user may never feel quite the same)
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To have done so many drugs, that one would expect you to be affected by drugs 24/7, even though you might not be, but you probably are.
James: Alex are you high?
Alex: Dude i dont even know i have done it like four times today already.
James: you must be perma-fried
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