the over-indulgence of pharmacueticals leading to the state of complete annihilation
ted's friends realised he'd reached pharmageddon, when they found him tits up in the gutter
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Massive loss and suffering, resulting from potential failure to develop a vaccine against Covid-19.
As the hopes of the world were focused on Big Pharma, the dates kept getting pushed back - probably October, maybe by the end of the year, sometime in 2022, well, the virus keeps mutating, so... - the number of infections and deaths mounted, and it came to be seen as Pharmageddon.