The spit that goes on a penis before insertion into a dry hole
Mike Tyson said he used prison lube when he had intercorse with that girl.
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Warm spit and/or the shitty residue left in a man's anus after taking an extremely sticky shit.
Hey, Tyrone. Earl raped you using prison lube, you bitch nigga.
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The blood and feces inmates naturally exude when larger inmates forcefully impale them in delicate areas, generally against their will.
Inmate 1: Heard you had to put your celly in his place last night. You didn't break him did you?
Inmate 2: Nah, he's just fine. He had plenty of prison lube in'em.