The shock from transitioning from one program to another on a computer.
Usually applies to art programs such as Paint Tool Sai, GIMP, Photoshop, etc. etc.
Person A: Hey, is he alright?
Person B: Yeah, he's just pissed that we don't have GIMP, so he has to use MS Paint instead. Just a little program shock, that's all.
Person A: Ah, okay.
Person C: *fetal position*