A refusal to trust that something, i.e. a film, that looks promising will in any way live up to that promise, and a persistent belief that it will, in fact, totally suck. Based on the sharp discrepancy between the heightened anticipation for Ridley Scott's "Prometheus" based largely on thrilling trailers, and the joyless experience of watching the disjointed, nonsensical & pretentious film.
"I gotta admit that the most recent trailer for "Alien: Covenant" looks kinda cool, but I refuse to get my hopes up and be excited for anything anymore--total "Prometheus Effect".
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Based on common reactions from the movie Prometheus. When a person leaves a theater thinking they liked a movie, but as the day goes on they think back on all the dumb shit that happened in the movie and by the end of the day they hated it.
Man, The Last Jedi is having the Prometheus Effect on me big time.