RLU is a preface to a message. It means Random Life Update.
Its used as a way of showing their love of you. Traditionally by sharing random AF details about their day. Most likely blurted out; not from lack of effort, more the need to tell you ASAP because you are their homie.
Message from BFF (Jane):
Jane: RLU - I just got a brain freeze because its FREAKING 20 degrees and I'm drinking a frappe. i wish there were hot frappes. the texture is so nice. its just too cold sometimes.
You: million dollar idea.
Jane: Finneas and ferb theme song plays**