rustled my jimmies

as others have stated: something has angered, upset, annoyed, aroused you
this is more of a side note on origin - I suspect the phrase was a spontaneous misquote of a line from the Weezer song "Say It Ain't So" ("...flip on the telly/ wrestle with Jimmy...")

man, that pic was disgusting.
yeah, that one rustled my jimmies

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Rustle My Jimmies

“That Really Rustled My Jimmies” is an expression that is used to convey feelings of discontent or discomfort in response to someone else’s post in imageboards and discussion forums, most notably on 4chan. To rustle one's jimmies means to make someone discontent or to bother someone.

Man 1: "This guy is your boyfriend? He's worthless!"

Man 2: "That really does Rustle My Jimmies man..."

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Rustling my jimmies

Verb: To erk someone. To be all up in their biz. To cause frustration and anxiety. Basically to piss someone off in a profound way. Or, to bother someone's friends named jimmy

You: yo mama...
Me: I can't stand it when you rustle my jimmies like that

~or~
You: hey jimmy and jimmy. You suck
Me: Dude stop rustling my jimmies and apologize

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rustles my jimmies

When something rustles your jimmies, it annoyed you or made you slightly angry.

Person 1: I can't believe Chipotle ran out of black beans!
Person 2: I know! That really rustles my jimmies.

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Rustle My Jimmies

Repositioning sexual organs. For males, repositioning of the penis and testicles. For females, repositioning of the breasts.

In awkward situations I like to rustle my jimmies

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