Systemic Sclerosis

Autoimmune, inflammatory condition causing body tissues to essentially thicken. Also known as Diffuse Scleroderma. There is commonly skin involvement, but in subtypes like Sine Scleroderma only internal manifestations are seen.

(Not to be confused with its less severe counterpart, Limited Cutaneous Systemic Sclerosis aka CREST Syndrome)

"The imaging for Sideroom 3 is back, seems his LCSS is flaring up."
"Wait, wasn't Systemic Sclerosis our main differential?"
"Yes but there was no indication of internal organ involvement on the scans."