A strange feeling of discomfort and agony that occurs when a piece of media (be it a song, a movie, a videogame, a book, etc.) that you are extremely fond of which was once relatively unknown to the general public suddenly becomes extremely mainstream via social media or some other means of publicity, thus kinda ruining the personal connection you had made with that piece of media.
*End of Beginning by Djo plays quietly in the background from a small Bluetooth speaker*
"Man, I used to really like Napoleon Dynamite but then everyone started quoting it all the time."
'Same here man, that's a classic case of The Djo Effect.'