A self-referential term used by friend or colleague who is never not fucked.
Said friend has existed in a negative space for too long a time and has accepted the constant life-fucking they're being subjected to, thus declaring him/herself The Mayor of Fucktown. Typically, they're genuinely happy, if not downright giddy, when someone joins them to wallow in shared misery.
Side-note: self-declared mayors are prone to greetings such as "Welcome to Fucktown!"
Chenille: "My boss just told us no more WFH Fridays (sigh).. welcome to Fucktown."
Ron: "I got fired for drinking on the job and a cop gave me a DUI on the way home. I'm The Mayor of Fucktown!"