Irritating, and annoyingly asking irrelevant rhetorical questions.
Boss: Hey, have you finished that report yet?
Me: Uh no.
Boss: But it's been 2 days. Get on it!
Me: WHY YOU ALWAYS VEXING ME!!
A common term used among House M.D. fans. (Particularly the r/okbuddyvicodin subreddit) Used as a reaction meaning literally anything. I don't know.
Someone: Wow, this is a weird meme!
Us: This vexes me.