To be a constant or great annoyance to a single or a group of individuals.
That kid won't stop coming over and trying to talk to us.
I know he's such a tickle in the anus!
I hate when Joe sticks my borrowed pencil up his nose and then tries to return it to me.
I feel you bro, he's such a tickle in the anus.
A derogatory synonym for the phrase, "Floats your boat," used to make fun of homosexuals.
Fag: "I really miss musical theatre. I think I'm going to go to the opening night of the new musical in town."
Me: "Whatever tickles your anus, man. Just leave me out of it."
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Used when someone is surprised or angry
1.) Gas prices went down 50 cents? Well, tickle my anus and call me Samantha!
2.) THAT BITCH SHARKEESHA TRIED TO STEAL MY MAN?! TICKLE MY ANUS AND CALL ME SAMANTHA, CUZ IMMA KILL A BITCH!
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