Any stupid and/or annoying male or female, who pulls in front of your car like you don't need sixteen to eighteen feet to stop without crashing into them, or anyone who gets on your nerves and it seems like if you shouted this term at them you would feel better about the whole confrontation.
Them: "you stupid son of a bitch, what were you thinking"
You: "I was thinking you are a Twat Waddler"
Female version of twat waffle, most likely possessing a large bush that she is in denial about.
Basically that girl in your friend group that sucks the life/fun out of everything, giving new definition to the term "Twat Waddler."
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