the yuri challenge is referring to a girl from ddlc. her name is yuri, and she committed suicide by stabbing herself. this is another way of saying "go do the sayori challenge" more creatively.
"you're so uncreative, everyone says sayori challenge"
"go yuri challenge then"
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The Yuri Challenge is referring to a girl from Doki Doki Literature Club. The Yuri Challenge has two different meanings. It either means "go stab yourself/go kill yourself" like the Sayori challenge except that you stab yourself. The other meaning is that it means to have s*x with a pen.
1. Go do the Yuri challenge because no-one likes you.
2. I'm going to do the Yuri challenge in {place}.