Up in someone's business, getting on someone's case, harping on someone, aggressively invasive or pursuant. Can be used to mean a woman whose aggressively pursuing a man. Can also be said all over my balls or just on my balls, or in terms of get off my balls or get off my back
My landlord was all up on my balls for the rent this month, dude needs to chill out
Your girl was all over your balls last night at that party
Man, why you all up on my balls, I already said sorry
Dude, get off my balls about it
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