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It means someone is So toxic and like to fuck around cheap fuck boys that theyre Just a Cancer hoe
Hot boy : Bro Hanna is Such a cancer hoe!
Cheap boy : I know right, shes So cheap dude.
When someone is So toxic you Just gotta pull out Cancer hoe.
Tom : UGH this cancer hoe Just told me that im ugly.
Sam : I feel u Man, dont worry.