When your high is so intense you finally catch the magical dragon you've been chasing. Upon catching this mystical beast, many are not able to come back to the physical world and die.
"Johnnys off trying to catch the dragon"
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When you contract more than one STD from one sexual partner, and end up with burning pee, and explosive diarrhea from your mouth.
I was with this girl last night night and now I think I am catching the dragon.