A large and annoying woman. Can be more cunt or more buffalo. If she's very fat and very annoying, can be classified as a "full blown cunt buffalo".
"Dude do you see that fat chick?!"
"Yea man, I talked to her. She's a full blown cunt buffalo!"
"Last night I was hitting on a cunt buffalo. To my credit though, she was more cunt than buffalo."
"Looks like Joe's going cunt buffalo hunting tonight. We gotta help a brotha out!"