to get fucked over by poor luck, often ending in a large disaster or great loss, for example having your entire party die in Darkest Dungeon.
Ah fuck man, I just got darkest dungeoned.
A challenging gothic roguelike turn-based RPG about the psychological stresses of adventuring. In other words, all your heroes are going to die and there's jack shit you can do about it.
Bob: Hey, Bill, did you play Darkest Dungeon last night?
Bill: Fuck that shit. I don't have any hair left to pull out, asshole.