A fancy yet amusing term. It basically means to defrag and delete a ton of files on your computer after you've accumulated a large sum of useless crappy files you no longer desire to have (or are getting in the way of important stuff).
Bob: Dude! My computer is running slow as shit! And I have so much crap on there I can't find half the files I need!
Joe: I think it's time you give your computer a digital enema.
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The act of plugging one end of an HDMI cable into a TV, and sticking the other end deep in your ass to see if it'll show up on-screen.
I shoved an HDMI cable in my ass. Digital Enema.