don't get your ham in a twist

this is a ruder version of:
don't get your knickers in a twist

but it literally means - don't get your fanny in a twist

it can also refer to ugly vaginas that appear "twisted" , telling a woman that she has a twisted ham can mean that they have a gross or ugly vagina or it can mean that they are unfeminine. Telling a man he has a twisted ham means that he is too feminine and or a male prostitute which would mean that his asshole has stretched out so much that it looks like an ugly vagina.

both person 1 and 2 are arguing
person1- * arguing and being a cunt*
person2- ' don't get your ham in a twist '