1: Someone or something that is being extremely annoying, obnoxious, or uncooperative.
2: Something that doesn't go your way, that you disagree with. (the score of a game) (someone's opinion)
3: A really, really, really nasty, blown out, stinky, saggy vagina.
4: Can substitute for every/any other word used to make fun of someone or something.
1: Quit trying to run the clock out and play you donkeytwat.
2: What a donkeytwat of a game.
3: This kid is acting a real donkeytwat.
4: If you keep being a donkeytwat I'm going to go into donkeytwatswatter mode on your ass.
5: IDC, she probably has a real donkeytwat anyways.