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draining the anaconda is another way of saying that you have to use the bathroom to urinate. you are draining youre bladder through your anaconda. The anaconda is for you to figure out. hopefully only applies to guys.
" Yo, get me another beer real quick."
"Nah man i gotta go drain the anaconda."
"Hey baby im feeling so hot right now... cmon let's go"
Uhhh shit, i have to go drain the anaconda.
*knocking on door*
"ONE SECOND, IM DRAINING THE ANACONDA!!!!"