An alternate way of saying "shut the fuck up".
Guy 1: Hey, I have a 15 foot penis.
Guy 2: Dude, fuck up the shut.
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STFU backwards, used to put the annoyance into such confusion that s/he automatically ceases talking for a moment to process what you just said.
"...and then I totally fucked that bitch in the ear."
"Dude! Up fuck the shut!"
"...What?"
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