The compulsive need to over accessorize, or cover up, to hide flaws.
"Damn that bitch is got some serious gaga syndrome."
"Don't complain dude, I don't want to see that shit without hair in its face."
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When a certain person becomes completely obsessed with Lady Gaga and tries to mimic her hair, makeup, clothing, and singing style he or she has Gaga Syndrome. But if you try to copy Lady Gaga's awesomeness only one thing can happen--you fail miserably. Side-effects might include making music videos where you say that you "Can't be Tamed", having wings in the video, or a huge amount of makeup on (*cough cough MILEY CYRUS cough cough*).
Did you see Miley Cyrus' "Can't Be Tamed" video?
Yeah! She has a serious case of Gaga Syndrome!
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A woman with Lady Gaga Syndrome is a woman who looks really attractive in some photos's but then ugly in others.
Guy 1: Hey man, look at Megan Fox, she's so hot.
Guy 2: Really hot. Too bad she has Lady Gaga Syndrome.
Guy 1: What?
Guy2: Y'know, sometimes Megan Fox looks really attractive in some photos, and then others looks like she has nothing but a plastic make up face on. Half fugly, half hot.
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When a celebrity can easily look like a completely different person in a different picture, scene, or setting.
Person 1: Who is that guy that plays Sirius Black?
Person 2: Gary Oldman
Person 1: Well then who plays Commissioner Gordon in the Bale Batman movies?
Person 2: Also Gary Oldman, he has Lady Gaga Syndrome.