to hurry up; to work or move faster; (pronounced like lead pencil)
This expression can probably be loosely interpreted as removing dead weight from a vehicle so that it can travel faster.
Bart Simpson: Come on Homer, get the lead out!
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It is typically used to mean that someone has obtained useful information that will help them to progress in a venture or task.
1."We finally got a lead on a girl"
2. "I've been looking for a job for weeks, but now I've got a lead from an old classmate on a potential opportunity."
3. "We will get a lead on this case soon"