A nerdy way of saying "what you said was bullshit"
Guy1: 2+2=4
Guy2: I beg to differ
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A political way of saying that someone disagrees with something they say.
I beg to differ about Mr Johnson's final assertion.
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Definition: I beg to differ is a word used by dimwits who think they always know what's going on.
Example:
Joe: Hey I don't think that's true
Jane: I beg to differ
Joe: No like it's literally on their website saying it isn't true.
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