The act of drinking heavily to induce a blackout intended to wipe out a bad memory.
Also used to describe the act of waking up from a blackout night and getting totally smashed again to keep those memories from surfacing.
Oh man, I can't believe I just banged that chick. Gimme a bottle of Wisers, I need a liquor lobotomy.
Jesus christ, I just saw your grandmother naked! Pass me that bottle, I need a liquor lobotomy!
Jill: Do you even remember what you did last night?
Jack: Uhhh....no...nothing. The entire night is a blank.
Jill: Drink this. You're gonna need a liquor lobotomy.