Prepared for an imminent activity. Believed to have originated during WWII, referring to the M1 Garand rifle, whose bolt automatically "locked" a round in the chamber when the rifle was "loaded" with a magazine, which could then be immediately fired without any further preparation required.
Frank: You still game for some blackjack and hookers?
Joe: locked and loaded and good to go bruh!
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A slang term to describe the pleasurable moment when you realise you've scored and you'll shortly be on your way home with a chick for a bit of action!
As Dave left the bar with his girlfriend, his mates asked where he was going. He simply said "I'm locked and loaded, and good to go!"
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