Make a sissy

To take a piss. To take a leak. To urinate

From the series "Dead Like Me" the character Rube played by Mandy Patinkin uses the euphamism as a character trait.

George, hold on a minute. I have to make a sissy, then I want to talk to you.

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Make Sissy

Take a piss, urinate, I have no idea about the origin, all I know is it’s used in Adam Sandler movies

Hang on guys, I gotta make sissy