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The state or condition of being tired of seeing a particular or overexposed meme.
"I'm getting meme fatigue from the "Keep Calm and Carry On" thing - it's making me want to lose control and break things."
The state a person is in if he/she/it is meme-ing too hard.
I'm really tired, man. My meme fatigue appeared after browsing /r/dankmemes for way too long.
running out of memes to post
you've been posting the same meme over and over, you have meme fatigue