While it may sound Hawaiian, this term is not. It refers to a demographic of people who have "No parents, no kids, no love interest." In other words child-less singles who's parents have passed away. Often used in context of guest lists at holiday parties. "Maybe we should invite him to Easter dinner. He's a nopa noki noli."
"Maybe we should invite him to Easter dinner. He's a nopa noki noli so he has nowhere else to go."