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Random
Usually an insult stating that a person is the most of something that the accuser has ever seen in his or her entire life.
2 guys bump into each other.
Alex: Hey, watch where you're going, you asshole.
Brian: You're a deuschbag, you loser.
Alex: You're a scrub of my career!
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A landmark bowel movement, followed by a tremendous sense of relief.
"I just had the shit of my career," Amy said with a sly grin.
A monsterous crap taken at work while in the midst of a busy time.
That was the "shit of my career."
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When something really bad happens.
Of equal or greater failure compared to if your career really ends.
Man, they made me take so many shots last night. They were trying to end my career.
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