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Just generally trippin', tweakin', weird, actin' a fool, blackin' out, goin' off. Not necessarily due to drugs, though that's the obvious reference.
Homie was on one, just buggin' like I shot his mom or something.
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to be under the influence of methamphetamines
i heard joe's been on one for the past three days
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To be under the influence of methamphetamines AKA ice,meth,speed,dope,etc.
Tuttie's on one man, he been smokin' ice all week!
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Just broke up with my girl and this alone time has me feelin' on one right now.
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to be high, faded, to have just smoked weed.
My man James was on one at the party.
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horny randy upforit madforit gaggingforit right-on-it etcetc
see above
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1. A game where the only opponents are two people playing against each other.
2. Also know as speedballing; a mixture of cocaine and herion, most often injected.
1. Jack says to Tommy, "Let's play a game of one on one"
2. After getting out of lock-up, I said to myself, "I'm 'bout ready to head downtown and gets me a one on one!!"
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