Agitated, upset, anxious. Cf. knickers in a twist.
Bitch, so I sold your children for crack! Don't get your panties in a knot!
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Don't do anything that will make you suffer.
If you do something foolish and don't get your panties in a knot.
pan-tee not
Slang:
a. a weak, effeminate, and often cowardly man
b. a sissy or fag
c. a person who lacks courage in facing danger, difficulty, opposition, pain.
Don't be such a Panty Knot
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