"Panty" (pronounced pan-tee) refers to a woman's underwear. A Panty Charmer is a person who flirts with, and gets along well with women, regardless of whether or not their aim is to get into their panties.
This term is similar to lady-killer, but it is less insidious.
Mike: "Nice panties Jill"
Jill: "You're clearly *not* a panty charmer, Mike"
Jill: *discretely reports Mike to HR*