A derogatory term commonly used by the online gaming community against Pre-Pubescent males who own a microphone but have not yet had their voices broken yet.
A "Pre-Pube" will often be characterised by his squeaky voice, often considered an annoyance during online gaming.
In some rare cases, a matured woman may be confused with a "Pre-Pube" due to their contrastingly higher voices to other male players.
A: *Squeaky Voice* Hello guys! I am new to this game, will you show me how to play?
B: God, who let the Pre-Pube join this game? Piss Off!