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noun: used to describe someone who is a retard, dumbass, fuckface or a any thing related to that
"That fuckin' pusshole took my money"
"Yo pusshole what's up?"
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When a chick gets fucked by a huge dick and her pussy and asshole become one big hole.
Holy shit Denise, that guy I went home with had such a thick dick, I now have a pusshole!
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A pusshole is a vagina, typically a stanky or fishy smelling one. It has a negative connotation.
It smells like dirty pusshole in here!