Feeling sad, down, or depressed because of having knowledge about something.
The red pill represents "knowledge, freedom and the (sometimes painful) truth of reality" so you can sometimes get the blues (sadness) from it.
The opposite of ignorance is bliss.
Person 1: Hey why you so down in the dumps lately?
Person 2: Just learned some more about the world, just the red pill blues I guess.
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Limiting someone's choices to two choices, rather than giving them a broad selection of choices.
Guy- Will you choose the red or blue pill?
Other guy- I don't take drugs, so I will choose not to take any pills or bullshit.
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