Despondency related to a lack of marijuana.
A play on the phrase "reefer madness," which is originally a 1936 anti-marijuana propaganda film.
Man, last week my mom smoked all my shit, and I'm broke. I had a bad case of reefer sadness.
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Depression and/or woe caused by a lack of marijuana.
โSorry dude, Iโve been feelin that reefer sadness since my plug moved to Portland.โ