To become heavily intoxicated to the point that one’s fly remains down (or in extreme cases, complete removal of outer layer below the waist) for the remainder of the bender, possibly to the extent that the genitals are exposed.
Raffy: Did you hear about Manny? Linda’s left him again. I think he’s pretty keen to rip a spinnaker tonight.
Eduardo: Oh Christ. Alright, but I can’t see Manny’s pee hole again.