Run my shit

to do what needs to be done or to take care of business.

Person one: "What are you gunna do today?"
Person two: "I gotta run my shit, bitch."

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run me my shits

Basically when two people are having a confrontation and one of them wants to fight, they will say "run me my shits". It's a long way around just saying "fight me right now".

Bob fucks Jim's girlfriend*
Bob: Bro I didn't mean to fuck her

Jim: Run me my shits
They proceed to fight*

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