Being so busy that you don't have time to stop to breathe and enjoy your life.
"Sarah is running the wheel so much that she'll have a heart attack before she is 30."
"You're on the fast track to a corner office if you keep running the wheel."
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1. To keep doing something long after one should have stopped.
2. To beat a dead horse.
3. Whatever you are doing has died, finished, been exploited to its fullest and you have chosen to continue... perhaps your a jerk.
a. Bill Watterson (creator of Calvin and Hobbes): "I think some of the reason "Calvin and Hobbes" still finds an audience today is because I chose not to run the wheels off it.
I've never regretted stopping when I did."
b. I think ol' Sly may be running the wheels off of the Rocky/Rambo franchises'.
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