A painful back-ailment caused by having a neighborhood bully try to run --- or ruin --- your life.
If Marty McFly hadn't intervened during his father's teenage years, George might have suffered from spinal biffida later in life, since it appears dat da Tannen legacy of running roughshod over fellow "spineless" humans even lasted into said loudmouth's "golden years"; we saw how he treated Marty, Jr. (well, at least da dude who he THOUGHT was "Little Man") --- verbally abusing him, bonking him on da head with his cane, etc.