Quite simply, a girl in a nightclub/bar that comes on way too strongly in a club, and who's behaviour can be considered to be 'over keen'.
Pete: Why didn't you go there bro? You were in, surely?!
Glyn: Nah, she was a bit of a Sweaty Megan
Pete: Ah, shocker...
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waking up covered in sweat after hallucinating on hemp or cannabis.
I ate way too many gummies last night and woke up with a sweaty Megan.
You better not eat that many gummies or you will get a sweaty Megan.
Bro, my sweaty Megan was so bad last night that I need a case of beer and a cold shower.