When you get drunk enough to take a disgustingly fat girl home who's willing to do anal, but her buttocks smells of death; so you grap a towel, get it moist with warm water, insert the towel into the cheeks and remove.
Mike: Hey kid! Guess what I'm gonna do to your sister tonight.
Kid: What?
Mike: TOWEL IT UP!
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Term used to refer to an individual's funny or painful incident. Often used in relation to surfing or contact sports.
"Hey, did you see Colmslater in the surf today? He really got toweled up."
"Don't try to start anything with those guys. They're about 25- you'd get toweled up."
Towel up, towelled up, gonna towel you up, need a towellin
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