A term originated by jacksepticeye meaning ready mad or committed.
Oh my twisty nipples are so twisty! I am ready for this spaghetti!
Grabbing someone by both nipples and twisting as hard as you can as a form of punishment for someone acting out in a negative way
Alright Ricky, get over here. Time for your sixteen nipple twisties.
Nipple Twistie is done in the movements of turning up an old radio or unscrewing a tight screw from a wall with your fingers also see tuningtokyo