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A combination of tobacco and marijuana smoked in the same pipe.
Hey, let's head down to the river and smoke some fuck-your-shit-uppers!
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When it hurts, but it is not your tummy and it is not your immediate shit - it is the upper shit.
Damn, I shouldn't have eaten that burrito, I can feel it in my upper shit. I am going to have a bad time at the toilet soon.