Sexually transmitted disease contracted through debauchery occurring in Las Vegas, Nevada. Typically preceded by heavy drinking and suggestive dancing; can also refer to the heavy desire one has to leave Vegas as quick as possible after spending a long trip there full of heavy drinking and suggestive dancing
After leaving Vegas,
Male A: "I haven't been feeling so hot, man."
Male B: "You should probably go to the doctor and get that checked out... wouldn't want to get the Vegas Itch."